Post-transplant lymphoproliferative disease.
نویسندگان
چکیده
منابع مشابه
Rituximab for post-transplant lymphoproliferative disease
Post-transplant lymphoproliferative disease (PTLD) describes a heterogenous group of lymphoproliferative diseases, occurring as a result of uncontrolled B cell proliferation in the context of post-transplant immunosuppression. The incidence depends on the type of transplant and immunosuppression used; the median time to onset is shorter for recipients of stem cell transplants (2 months) than th...
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Rituximab is a monocloncal antibody that binds specifically to CD20, an antigen expressed on the surface of mature and immature B lymphocytes. The binding of rituximab to CD20 results in cell lysis via the recruitment of immune effector functions; it has also been demonstrated to induce cell death via apoptosis. Rituximab (Mabthera®) is licensed in the UK for the treatment of Non-Hodgkin’s lymp...
متن کاملPost-transplant lymphoproliferative disorder.
BACKGROUND Posttransplant lymphoproliferative disorder (PTLD) is increasingly recognized as a serious complication of solid organ transplantation in both children and adults. Factors associated with increased risk of PTLD include mismatch of recipient and donor EBV serologic status (seronegative recipient with seropositive donor), and intensive drug-induced immunosuppression. METHODS AND RESU...
متن کاملPost-transplant lymphoproliferative disorders.
Post-transplant lymphoproliferative disorder is the most common malignancy, with the exception of skin cancer, after solid organ transplantation in adults. The incidence varies according to the transplanted organ and is often associated with Epstein-Barr virus. Prognosis is variable, due in part to the heterogeneity of the disease, which ranges from reactive plasmacytic hyperplasia to aggressiv...
متن کاملOcular post-transplant lymphoproliferative disorder
We report a case of an iris tumor with muttonfat keratic precipitates in a young patient after liver transplantation surgery. A 6yearold girl underwent liver transplantation for congenital biliary atresia and was subsequently immunosuppressed with oral cyclosporine. We examined her 5 years after transplantation because of a "white nodule in her left eye," which had been detected by her father o...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 1998
ISSN: 0931-0509,1460-2385
DOI: 10.1093/oxfordjournals.ndt.a027804